What We Do

SPC researchers in lab

About Us

The Centre, officially launched in 2015, is a unique Interdisciplinary Research Platform established to strengthen research capability and explore new synergies for the NTU Integrated Medical, Biological and Environmental Life Sciences (NIMBELS).

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Research Areas

The main research areas of the SPC are Food and Nutrition, Infection and Microbiome, and Environmental Sciences. SPC also develops metabolomics technologies and serves across areas of clinical, biological, and environmental sciences. These research/services are centered on the profiling of critical biomolecules such as metabolites and lipids using the state-of-the-art Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy technologies available at SPC.

We also offer services for processing and analyzing metabolomics and multi-omics data.

Core Services

In recent years, metabolomics have become increasingly important due to its potential to expand the understanding of how environmental factors and diseases influences human health. This can, in turn, lead to early disease diagnosis and prevention, or therapeutic strategies, resulting in improved healthcare and a higher standard of living. As such, the main research and service areas of the SPC are in the clinical, biological and environmental sciences. These research studies are centred on the profiling of critical biomolecules such as metabolites and lipids using the state-of-the-art Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS), and Nuclear Magnetic Resonance (NMR) Spectroscopy technologies available at SPC.

Singapore Phenome Centre offers a wide range of services. We help with project design, sample preparation, sample analysis, and data analysis.


 

UPLC untargeted
  • Profiling of metabolites in biological and clinical samples (urine, serum, plasma, fecal, etc) and samples from environmental sources via UPLC-MS
  • In-house plant metabolite database
  • Peptidomes
NMR
  • Metabolic profiling using NMR
  • Quantify over 100 lipoprotein sub-fractions from plasma
  • Quantify 150 metabolites in urine
  • Stable isotope flux analysis
  • De novo Structure elucidation
LC targeted quantification
  • Q-lipidomes (quantify 1800 lipid panels)
  • Amino acids
  • TCA cycle intermediates
  • A range of neurotransmitters
  • Tryptophan metabolism
  • Bile acid metabolism
  • Choline metabolism
  • Arachidonic acid metabolism
  • Purine metabolism
  • Short chain fatty acids 
  • Water soluble vitamins
  • Ceramides
  • Acyl-carnitines
  • Thiamine metabolism
  • Hormones
Development of new panelsCustomer-tailored targeted metabolite analysis
Mass Spectrometry Imaging
  • DESI
  • MALDI
Metabolomics and multi-omics data analysis
  • TidyMass for comprehensive untargeted metabolomics data processing and analysis
  • Biomarker analysis
  • Pathway analysis
  • Network analysis
  • And More
 Proteomics 
  • Deep Coverage Global Proteomics
  • High-Depth Global Proteomics
  • 4D Fast DIA Global Proteomics 
  • Target protein identification/Protein mixture identification
  • Deep Coverage Blood Global Proteomics
  • High-Depth Blood Global Proteomics
  • 4D-PRM/PRM-Targeted Proteomics
  • High-Depth Metaproteomics
  • 4D Fast DIA Phosphorylation proteomics
  • High-Depth Phosphorylation proteomics
  • 4D Fast DIA Acetylation proteomics 
  • High-Depth Acetylation proteomics 
  • 4D Fast DIA Ubiquitination proteomics 
  • High-Depth Ubiquitination proteomics 
  • 4D Fast DIA O-GlcNAc glycosylation proteomics 
  • 4D Fast DIA Intact N-glycopeptide proteomics