2023 Lee Kong Chian Distinguished Professors

Our esteemed speaker, Prof Joshua Angrist, Ford Professor of Economics at the Massachusetts Institute of Technology, is the 2021 Nobel Prize laureate in Economic Sciences, alongside Professors Guido Imbens and David Card. Prof Angrist and his co-laureates spearhead influential work in leveraging natural experiments to analyse causal relationships in complex social situations. These studies explore long-standing challenges of empirical research within economics and other social sciences, and guide policy-making in wider contexts such as school reform and the labour market.

Prof Angrist giving an overview of his work that garnered him the Nobel Prize to the audience.

Held on 27 July 2023, Prof Angrist's public lecture was co-organised by the Institute of Advanced Studies (IAS) and School of Social Sciences (SSS) at the Singapore Hokkien Huay Kuan Auditorium, NTU. Sponsored by the Lee Foundation, the public lecture was attended by close to 300 participants.  Prof Luke Ong, NTU Vice President (Research) was the Guest-of-Honour.

Titled "Escaping the Elite Illusion", Prof Angrist's lecture sought to debunk the notion that an education from highly selective, elite institutions is the sole path to economic success. His work suggests that the primary determinant of long-term prosperity is not the prestige of the educational institution, but instead the quality of teaching and the dedication of students which matter more than institution's branding. These factors contribute more significantly to social mobility, emphasising that the ability to succeed should not be restricted to a select few who attend elite institutions. Prof Angrist argued that elite schools do not necessarily offer a better education, and success is instead correlated with the abilities and efforts of the students who attend these schools. As such, he advocated for policies that promote and broaden equal access to quality education across all socio-economic levels.

[lef] Engaging Q&A session moderated by Prof Euston Quah.  [Right] Prof Luke Ong presenting memento to Prof Joshua Angrist.

His lecture was well-received by a diverse audience, including students, academics, and members of the public. The insightful presentation sparked lively Q&A session that was moderated by Prof Euston Quah, Albert Winsemius Chair Professor of Economics. One question raised was what Prof Angrist thought of the latest research from Chetty, Fleming and Friedman on “Diversifying Society’s Leaders? The Determinants and Causal Effects of Admission to Highly Selective Private Colleges”. He succinctly replied that the implications are the same – it is the quality of education that matters, not the brand name. There is little value-add from a student attending an elite private college who comes from the 99th-percentile income bracket in the USA. 

Students interacting with Prof Angrist after the lecture.

Zach Lee | Research Associate (Economics), HSS NTU

Our distinguished speaker, Prof Brian Kobilka, Nobel Prize in Chemistry 2012, is the Professor of Molecular and Cellular Physiology, and Hélène Irwin Fagan Chair in Cardiology at Stanford University School of Medicine. Held as a partner event of the Global Young Scientists Summit on 18 January 2023 at the Tan Chin Tuan Lecture Theatre, the Nobel public lecture was sponsored by Lee Foundation.

Prof Phan Anh Tuan (Chair, SPMS) presenting the memento to Prof Kobilka.

 Prof Kobilka’s talk was titled “Structural Insights into G Protein Coupled Receptor Activation: Implications for Drug Discovery”, which was the amazing work that let him to achieve the 2012 Chemistry Nobel Prize, along with Prof Robert Lefkowitz. He shared briefly about his own background and how he eventually went into science. The journey towards the discovery of the inner workings of G-protein Coupled Receptors was not smooth-sailing, especially with the limitations of science and technologies back in the 20th century. For the longest time, it has been a mystery as to how cells could react with their environment. In 1968, Prof Lefkowitz began to use radioactivity to trace cells’ receptors via the attachment of an iodine isotope. Fortunately, he was able to uncover various receptors and one of it is the β-adrenergic receptor. His research team eventually extracted it and gained an insight of the workings of this receptor.

In the 1980s, Prof Brian Kobilka joined Prof Lefkowitz’s group and successfully isolated the gene that codes for the β-adrenergic receptor. When they analysed the gene, they also discovered that the receptor was similar to one of the receptors in the eye that captures light. Eventually, it was later known that this family of receptors look and act in similar ways, now referred as G-protein-couple-receptors. Their research on this kind of receptor have contributed to approximately half of all medications used today. Furthermore, in 2011, Prof Kobilka achieved another breakthrough by capturing an image of the exact point where the β-adrenergic receptor is activated by a hormone and sent a signal into the cell.

Prof Brian Kobilka's enlightening talk on his breakthrough research in G Protein Coupled Receptor.

During the Q&A session, there were several intriguing questions asked such as the use of camelid antibody fragments (nanobodies), that only has the heavy chain, to stabilise the active state of GPCR structures, instead of the conventional antibodies that has light and heavy chains. Prof Kobilka shared that through trial and error, they managed to find the most suitable ones to stabilise the active conformation via a series of binding assays to ascertain the stability. Another question was asked how did becoming a researcher from a practical doctor impacted him in any ways. Prof Kobilka replied, “If I wasn’t a physician, I would probably not be in the field.” Close to 300 attendees attended the Nobel public lecture.

Prof Kobilka engaging in Q&A session with the enthusiastic students, moderated by Prof Zhao Yanli (Assoc Chair, Research & Graduate Education, CCEB).

Evelias Yan | Masters Student, School of Chemistry, Chemical Engineering and Biotechnology, NTU