There are 3 laboratories under the Biological and Chemical Processes Group:

• Biological Lab (N3-01b-07) 
• Biological Process Lab (N3.1-B3Ma-01)
• Chemical Lab (N3.1-B3b-04) 

Research Projects

Benign Surrogates for Tracing the Environmental Transmission Routes of Multi-drug Resistant (MDR) Bacteria and Norovirus in Health-care Settings
In collaboration with TTSH to investigate the environmental transmission routes and dynamics of MDR bacterial and Norovirus in health-care settings. Provide foundation for future development of infection control strategies. 

Principal Investigator: Associate Professor Wan Man Pun

Development of RPE-photoreceptors complex for investigation of age-related macular degeneration
A collaboration project with National Healthcare Group to create retina tissue complexes using advance biofabrication techniques

Principal Investigator: Professor Yeong Wai Yee

Biofabrication of Human Skin
This project aim to incorporate melanocytes within the printed tissue constructs to fabricate pigmented skin substitute that matches the patient’s skin color.

Principal Investigator: Professor Yeong Wai Yee

Biofabrication of Cardiovascular Tissue
The use of computer assisted technology allows controlled deposition and cells and biomaterials. In this study, extrusion-based bioprinting will be used as the primary mode of building the construct.

Principal Investigator: Professor Yeong Wai Yee

Biomolecular mediated computer
Conventional silicon-based computing, which has advanced by leaps and bounds in recent decades, is pushing against its practical limits. Biomolecular mediated computing could help take the digital era to the next level. 

Principal Investigator: Associate Professor Shu Jian Jun

There is 1 NTU research institute in the Biomedical Devices Group:

• Nanyang Institute of Technology in Health and Medicine (NITHM)

Research Projects

Cancer-detecting Bra
Dense breast tissue presents a higher risk of breast cancer developing than breast tissue with low density. This denser tissue is related to higher rates of false positive and false negative results from mammography or ultrasound, leading to unnecessary breast biopsy surgeries or failure to detect abnormal tissue. This project with Cyrcadia Health, Inc. developed an original device that has achieved FDA 510K clearance with 650 patients and the on-going final 173 BI-RADS 4/5 patient trail at JamesCare Comprehensive Breast Center in Ohio State University and The El Camino Hospital in Silicon Valley is positively tested and is being commercialized for product release in 2015. 

Principal Investigator: Associate Professor Ng Yin Kwee, Eddie

Biodegradable Shape Memory Foam Plug for Temporary Endovascular Embolization in Interventional Radiology
To develop a temporary embolization.

Principal Investigator: Associate Professor Huang Weimin

Multiphysics Modeling of Smart Hydrogel in BioMEMS
So far the six multiphysics models have been developed theoretically for simulation of the fundamental mechanism and performance of the smart hydrogels responsive to the six kinds of external stimuli in environment solutions respectively. They include (1) solution pH, (2) externally applied electric field, (3) pH coupled with electric field, (4) temperature, (5) glucose/carbohydrates, and (6) salt concentration/ionic strength. All the six models are based on the laws of mass and momentum conservations, and include the effects of multiphases (the 3-D solid polymeric matrix network, interstitial fluid and ion species) simultaneously and chemo-electro-mechanical coupled multi-fields. Computational domains are defined as covering both the smart hydrogel and surrounding solution, in which the moving interfaces between the hydrogel and solution are modeled approximately and the boundary conditions are imposed on solution edges. The work has been extended to transient simulation of controlled drug release from micro-hydrogel particles. 

Principal Investigator: Professor Li Hua

Multiphysics Modeling of Moving Deformable Cells in Microscale Hydrodynamic and/or Electric Fields
A two-fluid model is developed for flow characteristics of cell suspending in a fluid, considering the interaction between cell and hydrodynamic field, identified by the membrane mechanical force, in which the cell membrane is treated as an incompressible and elastic shell with a uniform thickness and allowed to undergo the stretching and bending deformation; the interaction between the cell and electric field, identified by the dielectrophoresis (DEP) force due to the cell polarization through the Maxwell stress tensor (MST) approach; and the interaction between the two cells, identified by the intercellular interaction force behaving as a weak attractive force at far distance but a strong repulsive force at near distance through the Morse potential model. 

Principal Investigator: Professor Li Hua

Developing Functionally Graded Titanium Based Implants for Biomedical Applications:
This project aims to develop functionally graded implants from titanium based alloy for biomedical applications

Principal Investigator: Professor Yeong Wai Yee

H-Man - Refinement and Clinical Evaluation of a novel, portable, inexpensive planar robot for arm rehabilitation after stroke
The primary aim is to assess to what extent our H-Man is suitable for rehabilitation purposes using a feasibility pilot clinical trial design involving stroke survivors. 

Principal Investigator: Associate Professor Domenico Campolo

Microfluidic approaches for point-of-care immune and vascular health profiling in type 2 diabetes mellitus
Development of novel microfluidics devices and biomarkers for real-time risk stratification and precision medicine approaches in diabetes. 

Principal Investigator: Associate Professor Hou Han Wei

Blood vessel-on-a-chip: A biomimetic model to study the immunomodulatory effects of vitamin D in atherosclerosis
Development of microengineered organ-on-chip technologies to investigate how vitamin D influences vascular inflammation and monocyte functions in atherosclerosis. 

Principal Investigator: Associate Professor Hou Han Wei

Research Projects

Model Development and Evaluation for Automatic Table Tennis Coaching

Principal Investigator: Associate Professor Chou Siaw Meng

Exercise footwear features for adults to counter age-related changes in gait muscle activity

Principal Investigator: Associate Professor Chou Siaw Meng

TPTP applied to Structural Sports Products in Mass Production
Thin C-plies and a special ARKEMA thermoplastic are used to develop a composite that can offer good fracture toughness, stiffness, shear properties and vibration damping. VARI and light RTM processes are adopted to establish a sports product application. 

Principal Investigator: Associate Professor Sunil Chandrakant Joshi

Electronic automatic gear transmission systems in light electric and human-powered vehicles

Principal Investigator: Associate Professor Yap Fook Fah