Publications

  1. J.H. Ch'ng, M. Muthu, K.K.L. Chong, J.J. Wong, C.A.Z. Tan, Z.J.S. Koh, D. Lopez, A. Matysik, Z.J. Nair, T. Barkham, Y.L Wang, K.A. Kline, "Heme cross-feeding can augment Staphylococcus aureus and Enterococcus faecalis dual species biofilms" The ISME Journal, 16(8): 2015-2026, 2022, https://doi.org/10.1038/s41396-022-01248-1.
  2. R.M. Traspas, T.S. Teoh, …Y.L. Wang, ….B. Reversade, "Loss of FOCAD, operating in the SKI mRNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis", Nature Genetics, 54(8) 1214-1226, 2022. doi: 10.1038/s41588-022-01120-0
  3. J.T. Bjerrum,* Y.L. Wang*, J.T. Zhang, L.B. Rils, O.H. Nielsen, J.B. Seidelin "Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets". International Journal of Biological Sciences, 18(5) 1813-1828, 2022, doi: 10.7150/ijbs.67112
  4. Q.Y. Hu, Y.T. Sun, P.H. Yuan, H.H. Lei, H.Q. Zhong, Y.L. Wang*, H.R. Tang*, "Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using ion-pair reversed-phase chromatography coupled with tandem mass spectrometry", Talanta, 238, 23059, 2022. https://doi.org/10.1016/j.talanta.2021.123059.
  5. Adav SS, Wang YL. Metabolomics Signatures of Aging: Recent Advances. Aging and Disease 2021;12:646-661.
  6. Alseekh S, Aharoni A, Brotman Y, Contrepois K, D'Auria J, Ewald J, Ewald JC, et al. Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices. Nature Methods 2021;18:747-756.
  7. Chen Q, Lai SM, Xu SH, Tan YR, Leong K, Liu DH, Tan JC, et al. Resident macrophages restrain pathological adipose tissue remodeling and protect vascular integrity in obese mice. Embo Reports 2021;22.
  8. Goh YQ, Cheam GX, Wang YL. Understanding Choline Bioavailability and Utilization: First Step Toward Personalizing Choline Nutrition. Journal of Agricultural and Food Chemistry 2021;69:10774-10789.
  9. Hu QY, Sun YT, Yuan PH, Lei HH, Zhong HQ, Wang YL, Tang HR. Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using ion-pair reversed-phase chromatography coupled with tandem mass spectrometry. Talanta 2022;238.
  10. Keerthisinghe TP, Yang Q, Chow A, Fang ML. Feeding state greatly modulates the effect of xenobiotics on gut microbiome metabolism: A case study of tetracycline. Journal of Hazardous Materials 2021;413.
  11. Liu M, Jiang J, Zheng J, Huan T, Gao B, Fei XC, Wang YL, et al. RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology 2021;55:16034-16043.
  12. Liu XJ, Zhao D, Zhao SJ, Li ZY, Wang YL, Qin XM. Deciphering the correlations between aging and constipation by metabolomics and network pharmacology. Aging-Us 2021;13:3798-3818.
  13. Peng B, Zhao HD, Keerthisinghe TP, Yu YX, Chen D, Huang YC, Fang ML. Gut microbial metabolite p-cresol alters biotransformation of bisphenol A: Enzyme competition or gene induction? Journal of Hazardous Materials 2022;426.
  14. Seviour T, Winnerdy FR, Wong LL, Shi XY, Mugunthan S, Foo YH, Castaing R, et al. The biofilm matrix scaffold of Pseudomonas aeruginosa contains G-quadruplex extracellular DNA structures. Npj Biofilms and Microbiomes 2021;7.
  15. Sun YT, Tang HR, Wang YL. Progress and Challenges in Quantifying Carbonyl-Metabolomic Phenomes with LC-MS/MS. Molecules 2021;26.
  16. Wu L, Han YQ, Zheng ZP, Peng GP, Liu P, Yue SQ, Zhu SA, et al. Altered Gut Microbial Metabolites in Amnestic Mild Cognitive Impairment and Alzheimer's Disease: Signals in Host-Microbe Interplay. Nutrients 2021;13.
  17. Xu TF, Chen LY, Lim YT, Zhao HD, Chen HJ, Chen MW, Huan T, et al. System Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle. Environmental Science & Technology 2021;55:1842-1851.
  18. Zhang LC, Xu TF, Zhang JT, Wong SCC, Ritchie M, Hou HW, Wang YL. Single Cell Metabolite Detection Using Inertial Microfluidics-Assisted Ion Mobility Mass Spectrometry. Analytical Chemistry 2021;93:10462-10468.
  19. Zhao FR, Li L, Chen Y, Huang YC, Keerthisinghe TP, Chow A, Dong T, et al. Risk-Based Chemical Ranking and Generating a Prioritized Human Exposome Database. Environmental Health Perspectives 2021;129.
  20. Zhu XY, Guo YY, Liu ZG, Yang JY, Tang HR, Wang YL. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Scientific Reports 2021;11.

  21. Wu, J. F., Zhu, X. H., Lin, H., Chen, Z. L., Tang, H. R., and Wang, Y. L. (2020) Gender differences in the bile acid profiles of APP/PS1 transgenic AD mice, Brain Research Bulletin 161, 116-126.
  22. Keerthisinghe, T. P., Wang, F., Wang, M. J., Yang, Q., Li, J. W., Yang, J. F., Xi, L., Dong, W., and Fang, M. L. (2020) Long-term exposure to TET increases body weight of juvenile zebrafish as indicated in host metabolism and gut microbiome, Environment International 139.
  23. Hu, Q. Y., Tang, H. R., and Wang, Y. L. (2020) Challenges in Analysis of Hydrophilic Metabolites Using Chromatography Coupled with Mass Spectrometry, Journal of Analysis and Testing 4, 140-162.
  24. Ding, L. F., Zhang, C. C., Liu, Z. G., Huang, Q. X., Zhang, Y. L., Li, S. P., Nie, G. J., Tang, H. R., and Wang, Y. L. (2020) Metabonomic Investigation of Biological Effects of a New Vessel Target Protein tTF-pHLIP in a Mouse Model, Journal of Proteome Research 19, 238-247.
  25. Chong, Y. C., Toh, T. B., Chan, Z. L., Lin, Q. X. X., Thng, D. K. H., Hooi, L., Ding, Z. B., Shuen, T., Toh, H. C., Dan, Y. Y., Bonney, G. K., Zhou, L., Chow, P., Wang, Y. L., Benoukraf, T., Chow, E. K. H., and Han, W. P. (2020) Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression, Hepatology Communications 4, 1362-1381.
  26. Chen, L. W., Zhang, J. T., Teh, J. P. Y., Cheon, B. K., Yang, Y. F., Schlundt, J., Wang, Y. L., and Conway, P. L. (2020) Comparative Blood and Urine Metabolomics Analysis of Healthy Elderly and Young Male Singaporeans, Journal of Proteome Research 19, 3264-3275.
  27. An, Y. P., Liu, S., Hao, F. H., Wang, Y. L., and Tang, H. R. (2020) Development and validation of an improved probabilistic quotient normalization method for LC/MS- and NMR-based metabonomic analysis, Chinese Chemical Letters 31, 1827-1830.
  28. Adav, S. S., and Sze, S. K. (2020) Hypoxia-Induced Degenerative Protein Modifications Associated with Aging and Age-Associated Disorders, Aging and Disease 11, 341-364.
  29. Wang, H. B., Yan, A. X., Liu, Z. G., Yang, X. M., Xu, Z. L., Wang, Y. C., Wang, R. M., Koohi-Moghadam, M., Hu, L. G., Xia, W., Tang, H. R., Wang, Y. L., Li, H. Y., and Sun, H. Z. (2019) Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli, Plos Biology 17.
  30. Peng, B., Liu, M., Han, Y., Wanjaya, E. R., and Fang, M. L. (2019) Competitive Biotransformation Among Phenolic Xenobiotic Mixtures: Underestimated Risks for Toxicity Assessment, Environmental Science & Technology 53, 12081-12090.
  31. Liu, C. X., Chen, F. F., Zhang, J. T., Liu, L. X., Lei, H. H., Li, H. P., Wang, Y. L., Liao, Y. C., and Tang, H. R. (2019) Metabolic Changes of Fusarium graminearum Induced by TPS Gene Deletion, Journal of Proteome Research 18, 3317-3327.
  32. Lin, H., An, Y. P., Tang, H. R., and Wang, Y. L. (2019) Alterations of Bile Acids and Gut Microbiota in Obesity Induced by High Fat Diet in Rat Model, Journal of Agricultural and Food Chemistry 67, 3624-3632.
  33. Keogh, D., Lam, L. N., Doyle, L. E., Matysik, A., Pavagadhi, S., Umashankar, S., Low, P. M., Dale, J. L., Song, Y. Y., Ng, S. P., Boothroyd, C. B., Dunny, G. M., Swarup, S., Williams, R. B. H., Marsili, E., and Kline, K. A. (2019) Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism (vol 9, e00626-17, 2018), Mbio 10.
  34. Kannaian, B., Sharma, B., Phillips, M., Chowdhury, A., Manimekalai, M. S. S., Adav, S. S., Ng, J. T. Y., Kumar, A., Lim, S., Mu, Y. G., Sze, S. K., Gruber, G., and Pervushin, K. (2019) Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-beta fibrils, Scientific Reports 9.
  35. Huang, Q. X., Lei, H. H., Dong, M. Y., Tang, H. R., and Wang, Y. L. (2019) Quantitative analysis of 10 classes of phospholipids by ultrahigh-performance liquid chromatography tandem triple-quadrupole mass spectrometry, Analyst 144, 3980-3987.
  36. Huang, Q. X., Lei, H. H., Ding, L. F., and Wang, Y. L. (2019) Stimulated phospholipid synthesis is key for hepatitis B virus replications, Scientific Reports 9.
  37. Han, L. F., Wang, P., Wang, Y. L., Zhao, Q. Y., Zheng, F., Dou, Z. Y., Yang, W. Z., Hu, L. M., and Liu, C. X. (2019) Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis, Frontiers in Pharmacology 10.
  38. Guo, N. L., Poh, T. Y., Pirela, S., Farcas, M. T., Chotirmall, S. H., Tham, W. K., Adav, S. S., Ye, Q., Wei, Y. Y., Shen, S. P., Christiani, D. C., Ng, K. W., Thomas, T., Qian, Y., and Demokritou, P. (2019) Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted Nanoparticle Inhalation Exposure-Induced Disease Risks, International Journal of Molecular Sciences 20.
  39. Dong, T., Zhang, Y. D., Jia, S. L., Shang, H. T., Fang, W. J., Chen, D., and Fang, M. L. (2019) Human Indoor Exposome of Chemicals in Dust and Risk Prioritization Using EPA's ToxCast Database, Environmental Science & Technology 53, 7045-7054.
  40. Adav, S. S., Park, J. E., and Sze, S. K. (2019) Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer's disease, Molecular Brain 12.
  41. Keogh, D., Lam, L. N., Doyle, L. E., Matysik, A., Pavagadhi, S., Umashankar, S., Low, P. M., Dale, J. L., Song, Y. Y., Ng, S. P., Boothroyd, C. B., Dunny, G. M., Swarup, S., Williams, R. B. H., Marsili, E., and Kline, K. A. (2018) Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism, Mbio 9.
  42. Ding, C. Y. G., Pang, L. M., Liang, Z. X., Goh, K. K. K., Glukhov, E., Gerwick, W. H., and Tan, L. T. (2018) MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria, Marine Drugs 16.
  43. Tan, Z. W., Teo, Z. Q., Tan, C., Choo, C. C., Loo, W. S., Song, Y. Y., Tam, Z. Y., Ng, S. P., Koh, H. Z., Ng, Y. S., Shochat, S. G., Yau, Y. H., Zhu, P. C., and Tan, N. S. (2017) ANGPTL4 T266M variant is associated with reduced cancer invasiveness, Biochimica Et Biophysica Acta-Molecular Cell Research 1864, 1525-1536.
  44. Tam, Z. Y., Ng, S. P., Tan, L. Q., Lin, C. H., Rothenbacher, D., Klenk, J., Boehm, B. O., Team, S. P. C., and Acti, F. E. S. G. (2017) Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus, Scientific Reports 7.
  45. Ohlson, S., Kaur, J., Raida, M., Niss, U., Bengala, T., Drum, C. L., Boehm, B., and Torres, A. R. (2017) Direct analysis - no sample preparation - of bioavailable cortisol in human plasma by weak affinity chromatography (WAC), Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 1061, 438-444.
  46. Ku, C. W., Tan, Z. W., Lim, M. K., Tam, Z. Y., Lin, C. H., Ng, S. P., Allen, J. C., Lek, S. M., Tan, T. C., and Tan, N. S. (2017) Spontaneous miscarriage in first trimester pregnancy is associated with altered urinary metabolite profile, Bba Clinical 8, 48-55.