My lab investigates the molecular mechanisms of cell adhesion and migration underpinning normal and pathological conditions, including inflammation and cancer. We focus on two protein families – integrins and kindlins. Integrins are transmembrane protein heterodimers that mediate cell-cell, cell-extracellular matrix, and cell-virus interactions. A large number of cytosolic proteins have been identified to regulate integrin function. We seek to understand the molecular basis of cross-talks between these regulators of integrin function. One family of these regulators known as kindlins has emerged as key regulators of integrin activation and signaling. We have shown recently that kindlin-3 is important in leukemic cell proliferation. We are now examining the signaling network of kindlins and its contribution to cancer progression and drug resistance.