News: LKCMedicine unveils new research centre to study dementia in Asians

By Kimberley Wang, Manager, Media and Publications, Communications and Outreach

On 25 April, LKCMedicine launched the Dementia Research Centre (Singapore) (DRCS) to better understand how dementia develops in Asians and to advance new strategies that will one day help to predict and delay the progression of the disease. 

The research centre will work with hospitals here to recruit patients with mild cognitive impairment – the earliest stage of dementia – to shed light on “Asian dementia” and capture the changes in the brain before dementia sets in.

Aside from this study, it will also work with NTU’s computer scientists and mechanical engineers to develop artificial intelligence-powered diagnostic solutions, such as using magnetic resonance imaging (MRI) scans to help clinicians accurately predict or assess dementia progression.

DRCS is part of LKCMedicine’s ongoing research efforts in neurodegenerative disorders under its Neuroscience and Mental Health research programme, in line with the School’s vision to transform healthcare.

Dementia is a syndrome, usually of a chronic or progressive nature, caused by a variety of brain illnesses that affect memory, thinking, behaviour and the ability to perform everyday activities. Worldwide, around 55 million people have dementia. This number is expected to more than double by 2050 as the proportion of older people in the population increases¹.  

Studies have found that the condition affects western and Asian populations differently. Asian patients with dementia are more likely to have lesions in the brain’s white matter, which connects and supports the cells in the brain. Patients with moderate to severe white matter lesions are known to deteriorate much faster.

Contributing to efforts to tackle dementia

At the launch, Guest-of-Honour Associate Professor Kenneth Mak, Director of Medical Services at the Ministry of Health and LKCMedicine Governing Board member, was hosted by NTU President Professor Subra Suresh, LKCMedicine Dean Professor Joseph Sung, and Director of DRCS Associate Professor Nagaendran Kandiah.

In his speech, A/Prof Mak said, “While dementia is not a new disease, much remains to be known about the condition, especially how it can further inform our national strategies and efforts. It is therefore timely that LKCMedicine sets up a Centre dedicated to multidisciplinary translational research on this condition.”

“I am confident that this new Centre will strengthen LKCMedicine’s efforts to drive transformative research with a national and global impact. Along with other research centres hosted at LKCMedicine, I am sure DRCS will make great strides in contributing to the future of medicine and healthcare through disruptive discoveries,” he added.

Prof Suresh said, “The Dementia Research Centre (Singapore) promises to offer us new avenues for developing a better understanding of neurodegenerative diseases.  The research from this Centre will also point to potential pathways to ensure a healthier ageing population, and benefit NTU’s efforts in shaping the future of medicine, continuing to improve medical education, and transforming healthcare.

“Besides working closely with local healthcare institutions, the Centre will also foster collaborations among scientists from many disciplines at NTU and our partner institutions to develop innovative solutions for dementia. This is very much aligned with the NTU 2025 strategic plan – to address Singapore’s national priorities and some of humanity’s grand challenges through strong interdisciplinary collaborations.”

Prof Sung added, “NTU’s initiative to advance research into dementia is very timely as the global population continues to age. Given that most of existing dementia literature is built on the western population, it is worthwhile for the University, led by its medical school, to focus on how dementia affects the Asian population and develop strategies that are tailored for this group. These findings could contribute to the national healthcare policy on dementia and the health economics of dementia. 

“By working closely with healthcare institutions in Singapore, as well as with experts from other disciplines within NTU, the Dementia Research Centre (Singapore) can serve as a platform where clinicians and scientists from different fields can come together to find solutions to address dementia.” 

LKCMedicine Vice-Dean (Research) Professor Lim Kah Leong, himself a neuroscientist who in 2020 led a multi-institutional team to secure a $10 million grant to delve into regenerative medicine for Parkinson’s disease, is confident the opening of the research centre will amplify the medical school’s research in neurodegenerative diseases.  

Watch the highlights of the DRCS launch here.

Large-scale study for early detection and intervention

DRCS is headed by A/Prof Kandiah, who is also a clinician-scientist with the National Medical Research Council. The team is advised by a panel of renowned neuroscientists from Canada, Australia, and the UK.

While the pathologies underlying dementia can begin decades before the symptoms emerge, the early stage of the condition, called mild cognitive impairment, is often overlooked because the onset is gradual. Common signs at this stage include forgetfulness, losing track of time, and becoming lost in familiar places.

A/Prof Kandiah said, “The challenge with treating dementia is that if it is not picked up early, you miss the boat. Once you lose brain cells, there is nothing we can do to reverse that. What we do know now is that there are certain mechanisms that could take place in the brain as early as 30 years before someone develops dementia.

“For patients with mild cognitive impairment, the risk of developing dementia increases by 10 to 15 per cent every year. This is why we are focusing on mild cognitive impairment – to allow for early detection and intervention.”

To this end, the research centre has embarked on the Biomarker and Cognitive Impairment Study (BioCIS), a five-year longitudinal study to look at what is happening to the brain at the very earliest stages of dementia and even before brain changes set in. 

It aims to recruit 1,500 Singapore participants between 30 and 95 years old and is partnering hospitals here, including the Institute of Mental Health and Khoo Teck Puat Hospital, to recruit patients with mild cognitive impairment. 

Participants will go through a comprehensive cognitive assessment, which includes brain MRI scans, a neuropsychological assessment, and blood sample collection to measure markers in blood that are associated with cognition. These participants will be followed up over a five-year period to identify changes in cognition and health status. 

A combination of these tests and the blood biomarkers, digital biomarkers and neuroimaging markers can help researchers detect early brain changes and determine whether a person is at risk of developing dementia.

Members of the public who are keen to find out if they are at risk of developing dementia can do a simple online self-assessment and use the risk calculator on the DRCS website. Those who meet the criteria for the study will be invited to participate in the study.

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Footnotes:

¹ Dementia fact sheet, World Health Organization, 2 Sep 2021